J C Monahan Separation (2024)

1. JC Monahan: Breaking My Silence - Boston Magazine

6 apr 2021 · I made two major decisions: I filed for divorce after more than 15 years of marriage and signed off at WCVB, the place that had shaped my career ...
For many years, NBC Boston anchor JC Monahan had a secret—and keeping it nearly cost her everything.

7 apr 2021 · NBC10 Boston's JC Monahan is sharing her struggles with depression and “debilitating” anxiety. Read more on Boston.com.
NBC10 Boston’s JC Monahan is sharing her struggles with depression and “debilitating” anxiety with the hope that opening up about her experiences may help others grappling with mental health issues. In […]

20 apr 2021 · Cross-interaction-driven phase separation is the phase separation ... Monahan Z, Ryan VH, Janke AM, Burke KA ... JC, Li CH, Guo YE, Day DS, ...
Biological phase separation is known to be important for cellular organization, recently extending to a new class of biomolecules that form liquid-like droplets coexisting with the surrounding cellular, or extracellular environment. These droplets are ...

Bottom: on the other side, original physiological LLPS partially or totally lose phase separation, termed loss of phase separation (LoPS). ... Monahan et al., ...
Abstract. Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compart

8 okt 2019 · More specifically, phosphorylation is a key suppressor of phase separation in neuronal proteins such as FUS (Monahan et al., 2017), CPEB4 ...
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Biomolecular condensation is emerging as an essential process for cellular compartmentalization. Formation of biomolecular condensates can be driven by liquid-liquid phase separation, which arises from weak, multivalent interactions among proteins and ...

... J.C.; Hannett, N.M.; et al. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Cell 2018, 175, 1842 ...
Liquid–liquid phase separation (LLPS) is a biophysical process that mediates the precise and complex spatiotemporal coordination of cellular processes. Proteins and nucleic acids are compartmentalized into micron-scale membrane-less droplets via LLPS. These droplets, termed biomolecular condensates, are highly dynamic, have concentrated components, and perform specific functions. Biomolecular condensates have been observed to organize diverse key biological processes, including gene transcription, signal transduction, DNA damage repair, chromatin organization, and autophagy. The dysregulation of these biological activities owing to aberrant LLPS is important in cardiovascular diseases. This review provides a detailed overview of the regulation and functions of biomolecular condensates, provides a comprehensive depiction of LLPS in several common cardiovascular diseases, and discusses the revolutionary therapeutic perspective of modulating LLPS in cardiovascular diseases and new treatment strategies relevant to LLPS.

30 jun 2020 · DNA-dependent protein kinase–mediated phosphorylation of the FUS LCD inhibits phase separation (Monahan et al., 2017; Murray et al., 2017).
Zhang and colleagues summarize phase separation and transition in the assembly of autophagosome formation sites and triage of protein condensates for degra

Ferreon, J. C. et al. Acetylation disfavors tau phase separation. Int. J. Mol. Sci. 19, 1360. (2018). 13. Monahan ...

A 4 mm length of the separation channel can be observed for separation. ... Karlinsey, J. M., Monahan, J., Marchiarullo ... McDonald, J. C., Duffy, D. C., Anderson, ...

2 aug 2021 · Methods to study liquid separation are being developed (to observe LLPS); we review them below. ... Monahan, Z. et al. Phosphorylation of the ...
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases. In this review, we describe our current understanding of LLPS and summarize its physiological functions. We further describe the role of LLPS in the development of human diseases. Additionally, we review the recently developed methods for studying LLPS. Although LLPS research is in its infancy—but is fast-growing—it is clear that LLPS plays an essential role in the development of pathophysiological conditions. This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.

1 aug 2018 · BF12 Bobot BFilliâtre J-CSeparation predicates: a taste of separation ... LM10 Leino KRM, Monahan R (2010) Dafny meets the verification benchmarks ...
AbstractFraming is important for specification and verification, especially in programs that mutate data structures with shared data, such as DAGs. Both separation logic and region logic are succes...